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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by jerrympls on April 21, 2004, at 22:12:46
I know many antipsychotics antagonize 5-HT2 receptors - but are there any "psychiatric" meds that also antagonize 5-HT3?
Thanks in advance
Jerry
Posted by Vanillintabaktöne on April 21, 2004, at 22:29:58
In reply to Which meds antagonize 5-HT3 receptors?, posted by jerrympls on April 21, 2004, at 22:12:46
> I know many antipsychotics antagonize 5-HT2 receptors - but are there any "psychiatric" meds that also antagonize 5-HT3?
>
>
> Thanks in advance
> Jerry
Hello jerry,Agonism or if you prefer, Stimulation of 5-HT 3 receptors induce nausea + vomiting. In oncology, agents such as ondansteron ([Zofran] there are a few others)are essentially 5-HT 3 receptor antagonists and are prescribed to alleviate chemotherapy induced nausea/vomiting and are efficacious in doing so.
Antiemetic efficacy results from a simultaneous action at peripheral and central 5-HT3-receptors. Other peripheral actions include reduction of secretion and diarrhea caused by increased intestinal serotonin content (e.g. in carcinoid syndrome), a limited antiarrhythmic activity and a reduction of experimentally induced pain. CNS effects comprise anxiolysis, attenuation of age-associated memory impairment, reduction of alcohol consumption in moderate alcohol abuse and an antipsychotic effect in patients with parkinson psychosis. In migraine, 5-HT3-receptor antagonists show moderate efficacy, as well..........read more @http://nootropics.com/5-ht3/
Hope that offers some insight.
Posted by linkadge on April 22, 2004, at 7:29:17
In reply to Re: Which meds antagonize 5-HT3 receptors?, posted by Vanillintabaktöne on April 21, 2004, at 22:29:58
Posted by King Vultan on April 22, 2004, at 7:42:46
In reply to Which meds antagonize 5-HT3 receptors?, posted by jerrympls on April 21, 2004, at 22:12:46
> I know many antipsychotics antagonize 5-HT2 receptors - but are there any "psychiatric" meds that also antagonize 5-HT3?
>
>
> Thanks in advance
> Jerry
linkadge mentioned Remeron, which is the only AD I'm aware of that is noted for this. If you include antipsychotics, clozapine (Clozaril) and olanzapine (Zyprexa) both antagonize 5-HT3 receptors.Todd
Posted by Sad Panda on April 22, 2004, at 11:41:40
In reply to Re: Which meds antagonize 5-HT3 receptors?, posted by King Vultan on April 22, 2004, at 7:42:46
> > I know many antipsychotics antagonize 5-HT2 receptors - but are there any "psychiatric" meds that also antagonize 5-HT3?
> >
> >
> > Thanks in advance
> > Jerry
>
>
> linkadge mentioned Remeron, which is the only AD I'm aware of that is noted for this. If you include antipsychotics, clozapine (Clozaril) and olanzapine (Zyprexa) both antagonize 5-HT3 receptors.
>
> Todd
>
>Remeron is excellent for my Effexor induced nausea. I imagine that it would be good for SSRI induced nausea too.
Cheers,
Panda.
Posted by jerrympls on April 22, 2004, at 19:47:53
In reply to Re: Which meds antagonize 5-HT3 receptors?, posted by Vanillintabaktöne on April 21, 2004, at 22:29:58
Thanks!
Just wondering - because when I have been given Zofran for nausea in the past - it almost acts as an antidepressant for me. It also
This is the end of the thread.
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