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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 10 of 10. This is the beginning of the thread.
Posted by jaby on July 2, 2003, at 17:05:31
Anyone had any success with this? There is a story out of Japan using one called talipexole.
Posted by Edgefield on July 2, 2003, at 17:12:46
In reply to Dissociation/derealization helped by a DA agonist?, posted by jaby on July 2, 2003, at 17:05:31
I've never heard of this, but I will do some research. If anyone find out anything I am very interested.
Faith
Posted by ace on July 3, 2003, at 0:42:59
In reply to Dissociation/derealization helped by a DA agonist?, posted by jaby on July 2, 2003, at 17:05:31
This is very interesting, even more so since I've just started a dopamine antagonist- Zyprexa. I havent actually heard of this hypothesis, but I have heard that derealization and depersonalization symptoms result from excessive stimulation of the 5-HT2 receptor. This is why Lamotrigine is used- often with good results. I must say my experience is consistent with this: when I added Lithium to my Nardil after a while derealization got real bad- Lithium increases serotonin. But with the dopamine thing, I'm exploring it. If Zyprexa doesn't work (for my OCD and only a bit remaing derealization after Nardil knocked it in the head) I will then go on to dopamine agonists- 1. Mirapex, 2. Bromocriptine, and more I will research.
Good luck to you!
Ace.
Posted by jaby on July 3, 2003, at 9:42:27
In reply to Re: Dissociation/derealization helped by a DA agonist? jaby, posted by ace on July 3, 2003, at 0:42:59
Do you have any studies supporting the 5-HT2A hypothesis? I would be interested in any sources citing lamictal as acting on 5-HT2A as well as I have done quite a bit of research on the drug and have not come accross it. If you have problems similar to mine, you might try lamictal if you haven't. I got 100% amelioration of all of my symptoms for a few weeks on it and then it pooped out. I have been trying to no end to determine what mode of action might have caused such a robust response. Thanks!
Posted by Edgefield on July 3, 2003, at 19:01:47
In reply to Re: Dissociation/derealization helped by a DA ACE, posted by jaby on July 3, 2003, at 9:42:27
So you had total relief from derealization when you took Lamictal :) I am very glad to hear this and I will discuss this with my pdoc :)))
May I ask what caused your derealization? Mine started with the first panic attack, and I've found about 75% relief since I began taking Wellbutrin. Maybe I need a small dose of Lamictal to get rid of the remaining 25%.....
Faith
Posted by jaby on July 4, 2003, at 18:12:25
In reply to Re: Dissociation/derealization helped by a DA ACE jaby, posted by Edgefield on July 3, 2003, at 19:01:47
mine started with a panic attack that turned into constant GAD. I have now since been dxed BPII. Lithium has helped. Lamictal knocked out all my problems the first day i took it. It gradually pooped out even with dosage increases and then seemed to cause a toxic reaction.
Posted by Edgefield on July 4, 2003, at 18:23:27
In reply to Re: Dissociation/derealization helped by a DA ACE, posted by jaby on July 4, 2003, at 18:12:25
What dosage of Lamictal did you begin with, and please explain about the toxic reaction? I'm looking forward to Monday, so that I can discuss taking a low dosage of this med. to see if it helps with my derealization.
God Bless
Posted by dave1 on July 5, 2003, at 18:40:55
In reply to Dissociation/derealization helped by a DA agonist?, posted by jaby on July 2, 2003, at 17:05:31
What are the best common things for derealization, depersonalization, dissociation?
I only get help from ativan which I take way to much of.Daved
Posted by Edgefield on July 5, 2003, at 20:08:24
In reply to Re: Dissociation/derealization helped by a DA agonist?, posted by dave1 on July 5, 2003, at 18:40:55
Dave, I just posted the same question. Like yourself Ativan seems to help me, but I only take about .25mg a day. I'm also taking Wellbutrin which has helped with about 75% of the derealization.
I pray that we get some answers.
Edgefield
Posted by ACE on July 7, 2003, at 22:51:58
In reply to Re: Dissociation/derealization helped by a DA ACE, posted by jaby on July 3, 2003, at 9:42:27
> Do you have any studies supporting the 5-HT2A hypothesis? I would be interested in any sources citing lamictal as acting on 5-HT2A as well as I have done quite a bit of research on the drug and have not come accross it. If you have problems similar to mine, you might try lamictal if you haven't. I got 100% amelioration of all of my symptoms for a few weeks on it and then it pooped out. I have been trying to no end to determine what mode of action might have caused such a robust response. Thanks!
Hi!,
I'll check out the references tonight. Zyprexa is working preety cool. I'll be back soon!
Ace.
This is the end of the thread.
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