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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by ace on March 12, 2003, at 0:16:35
I have heard conflicting reports on this. Most people think of the AP's as dopamine/serotonin antagonists. I believe they are all dopamine antagonists - which is helpful for severe OCD.
But with regard to serotonin some people say they are serotonin antagonists. others serotonin agonists.]
Even Toby, a neurologist and psychiatrist who used to post in the early days of this site, stated, "zyprexa causes and all-around boosting of serotonin"
So, what is it. Who knows its affinity for each serotonin receptor? Is their both going on here??
Thanks,
Ace.
Posted by djmmm on March 12, 2003, at 8:37:33
In reply to is ZYPREXA a serotonin agonist or antagonist????, posted by ace on March 12, 2003, at 0:16:35
I believe Zyprexa is primarily an antagonist within the serotonin system, it is an antagonist at the 5ht-2a, 2c, 5ht-6, 5ht-3 receptors. However, antagonism at the 5ht-2a and D2 sites can cause 5ht-1a AGONIST activity.
Several dopamine receptors are effected: D1 through D4, it's a histamie antagonist, and alpha-1 receptor antagonist, as well as an acetylcholine receptor antagonist.. Zyprexa has some effect on benzo receptors, too.
Posted by JohnL on March 13, 2003, at 5:27:32
In reply to is ZYPREXA a serotonin agonist or antagonist????, posted by ace on March 12, 2003, at 0:16:35
I'm not sure how the agonist or antagonist thing is all that important. All that really counts is how it makes you feel when you try it.
Regardless of how the drug actually works, clinical studies have shown that Zyprexa significantly elevates serotonin, norepinephrine, and dopamine levels. This is most pronounced when combined with Prozac. How exactly this happens...whether it be agonism or antagonism...I don't know and don't care. I like the way it helps my mood, and that's the main thing I care about.
> I have heard conflicting reports on this. Most people think of the AP's as dopamine/serotonin antagonists. I believe they are all dopamine antagonists - which is helpful for severe OCD.
>
> But with regard to serotonin some people say they are serotonin antagonists. others serotonin agonists.]
>
> Even Toby, a neurologist and psychiatrist who used to post in the early days of this site, stated, "zyprexa causes and all-around boosting of serotonin"
>
> So, what is it. Who knows its affinity for each serotonin receptor? Is their both going on here??
>
>
> Thanks,
> Ace.
Posted by cybercafe on March 14, 2003, at 14:28:04
In reply to Re: is ZYPREXA a serotonin agonist or antagonist????, posted by djmmm on March 12, 2003, at 8:37:33
> I believe Zyprexa is primarily an antagonist within the serotonin system, it is an antagonist at the 5ht-2a, 2c, 5ht-6, 5ht-3 receptors. However, antagonism at the 5ht-2a and D2 sites can cause 5ht-1a AGONIST activity.
>
> Several dopamine receptors are effected: D1 through D4, it's a histamie antagonist, and alpha-1 receptor antagonist, as well as an acetylcholine receptor antagonist.. Zyprexa has some effect on benzo receptors, too.yeah you would say zyprexa is a 5ht-2a, 2c, 5ht-6, 5ht-3 antagonist
but a serotonin agonist, cuz in general, if you block a receptor, there is more free to float in the synaptic gap and bind to other receptors
This is the end of the thread.
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