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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by SLS on January 21, 2003, at 12:25:03
Nefazodone is being withdrawn from all European markets. The reason cited is an unacceptably high rate of liver failure, including 26 deaths. No such plans have been announced for the US.
http://www.altapharm.org/college/news/PharmNewsDetails.cfm?ID=3600
- Scott
Posted by noa on January 21, 2003, at 18:58:40
In reply to Nefazodone to be withdrawn from European markets., posted by SLS on January 21, 2003, at 12:25:03
Another thing for me to discuss with my pdoc next visit. Thanks for the info, Scott. Btw, how are you?
Posted by SLS on January 22, 2003, at 8:06:41
In reply to Re: Nefazodone to be withdrawn from European markets., posted by noa on January 21, 2003, at 18:58:40
Thanks for asking, noa.
I have not made any progress towards finding an effective treatment. I have decided just this last week to look for a new doctor. My old one all of a sudden got conservative on me, after promising me innovative treatments. In two years, the only things he did was to beat to death Parnate, Effexor and Nardil. What a waste of two years. I made an appointment to see my former doctor in Princeton to see if he can come up with anything new. If not, he provides an excellent source for referrals to specialists in TRD.
I'll probably remain on Nardil + desipramine for the time being since it provides enough functionality to advocate for myself.
Last August, I experienced a wonderful remission that lasted for about a week or two. While on Nardil, I was forced to discontinue imipramine (TCA). I experienced a discontinuation rebound-improvement antidepressant response that allowed me to join the life of the living briefly. My God! I can hardly believe that normal people feel that way all of the time. It's funny, though. It doesn't seem so much that I become different than the world becomes different.
* It has been postulated that it might be a metabolite of nefazodone that is responsible for liver toxicity. I don't know which one. Perhaps Remeron would act to substitute for the 5-HT2 receptor blockade of Serzone. Another possibility is to substitute Serzone with trazodone, a sister drug with a similar pharmacological profile. I couldn't guess whether the FDA will see it necessary to go beyond the black-box warning it has already mandated for Serzone.
Good luck on this matter.
- Scott
Posted by noa on January 22, 2003, at 19:18:41
In reply to Re: Nefazodone to be withdrawn from European markets., posted by SLS on January 22, 2003, at 8:06:41
Hey, Scott, thanks for remembering that I need the 5HT2 receptor blockade!
Glad you got at least a "taste" of euthymia. Maybe that keeps you motivated to keep on trying?
Good luck.
This is the end of the thread.
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