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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by Passion on January 11, 2003, at 15:48:47
I keep hearing about people being on Wellbutrin and also Zyprexa at the same time. This doesn't really make sense to me, as the two are cancelling each other out? Wellbutrin as most may know inhibits the reuptake of dopamine and norepinephrine, in effect increasing the levels of these neurotransmitters in the synapse.
Zyprexa is a dopamine ANTAGONIST, that's the whole point and is why it works against schizophrenia. It blocks dopamine receptors (D1-D4) and keeps it from binding. It also antagonizes norepinephrine receptors.
Does anyone have a clue why lots of people are on this combo that seems to cancel each other out? maybe I'm missing something.
Thanks in Advance
Passion
Posted by cybercafe on January 12, 2003, at 17:46:42
In reply to Wellbutrin + Zyprexa, posted by Passion on January 11, 2003, at 15:48:47
> I keep hearing about people being on Wellbutrin and also Zyprexa at the same time. This doesn't really make sense to me, as the two are cancelling each other out? Wellbutrin as most may know inhibits the reuptake of dopamine and norepinephrine, in effect increasing the levels of these neurotransmitters in the synapse.
>
> Zyprexa is a dopamine ANTAGONIST, that's the whole point and is why it works against schizophrenia. It blocks dopamine receptors (D1-D4) and keeps it from binding. It also antagonizes norepinephrine receptors.
>
> Does anyone have a clue why lots of people are on this combo that seems to cancel each other out? maybe I'm missing something.
> Thanks in Advance
> Passion
>i'd imagine zyprexa's affinity for different receptors to not be the same ...
i.e. those that it has the most affinity for are probably most responsible for its therapeutic effect...
the additional dopamine/norepenephrine can go to the receptors that need it more (and are antagonized less)
just guessing
Posted by vagen on January 13, 2003, at 13:13:07
In reply to Re: Wellbutrin + Zyprexa, posted by cybercafe on January 12, 2003, at 17:46:42
IT does seem strange.
Maybe it works (I am assuming) that if we are not schizo, then it stops the other things.I am taking wellabutrin and risperdone.
There have been studies saying it works very well for bp stuff.
I am on day three, so I am not sure.
Posted by cybercafe on January 13, 2003, at 13:50:08
In reply to Re: Wellbutrin + Zyprexa, posted by vagen on January 13, 2003, at 13:13:07
> IT does seem strange.
> Maybe it works (I am assuming) that if we are not schizo, then it stops the other things.
>
> I am taking wellabutrin and risperdone.
> There have been studies saying it works very well for bp stuff.
> I am on day three, so I am not sure.do you mind if i ask if you are type 1 or 2 and what dosages you are taking?
do you get any movement disorders?
Posted by lostsailor on January 16, 2003, at 23:00:53
In reply to Re: Wellbutrin + Zyprexa, posted by cybercafe on January 13, 2003, at 13:50:08
points: wellbuterin is often indicated for ppl with bi-polar one or two dis b/c it "appears" there is less of a likelyhood to kindle a manic episode
many of the aytypical anti pshcys ure now being proven effective for b/p's during acute manic episodes and also are an ajunct to "daily treatment".
Interesitng...I have BP dis order (if not on proper meds a have a tend to be depressed), panic dis or GAD . buspar was not used for GAD, as benzos and ssris were, but to help ignite my ssri.
risperdal seemd to be a great treament ajunct but may also be used just to induse sleep, same as zyprexa or seriquil but of the "new" aytipical anti psychs. but ztyprexa and seriquil have a less likelyhood of causing EPS syndrome or movements. all three though help to, just like lithiun then and now be used as coexistig treatment of more so lately mainstay treatment.
i am amazed at times, the way i feel i understand psychophamacollogy when the doc see my point and indicates he is using the undesireable side efffect of one med to maximize the effective ness of another.....perhaps they just do it for all the cool pens and coffee mugs they getlol
~tony
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