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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 3 of 3. This is the beginning of the thread.
Posted by glenn on October 21, 2002, at 14:47:09
For all Treatment resistants, difficult patients and those with “ personality disorder”.
I am sure that some of us will be familiar with these terms, they don’t leave much scope for hope do they?
However I think that poor diagnosis , treatment and a lack of medications that work in ways different to ssris, tcas and maois, is the problem , not us!!I have recently come across some interesting information about 2 meds that work in different ways and a number of supplements / herbs that may be of help to some of us.
2 New Meds in Development.
Both nemifitide and ORG 34517 are meds I believe in phase 111 trials which I assume is fairly well along the line to us being able to have a go. If someone can estimate how long please do. Please be optimistic.
They are not metoo drugs such as duloxetine and lexapro which will no doubt help some, but are primarily designed to work on different systems, which is useful in that it gets away from the idea that serotonin (or for that matter noradrenaline or dopamine) is the key to depression.To check on these two either go to google and type them in or try the following links
http://chinspirations.com/mhsourcepage/newsflash-0702.html
http://www.cinp2002.com/cgi-bin/ciagenda and follow the link for nemifitideOther Substances.
The following substances may be helpful for some:
Tryptozen.
Basically a milk protein developed by the French and actually patented, it has some anti cortisol properties and some research. It is primarily marketed as anti stress and anxiety.
Try the following link:
http://www.pnt-200.com/pnt200.html
Relora.A mixture of two Chinese herbs which has been found to reduce cortisol and substantially increase dhea. Again it is primarily marketed as anti stress and anxiety but it is interesting that Owen Wolkowicz has successfully used dhea to treat depression.
A good link is:
http://relora.com/News/pr3.htm
As is:
http://www.solanova.com/info_relora.asp?slno=0
Sutherlandia.
A South African herb which has been used by many years by the Zulus as a mood enhancer.
There is some concern about one of its ingredients - cannavine, you may want to check this out.
Good links are:http://www.wellness-net.com/depression_frame.htm
http://sutherlandia.org/toxicity.html
Pikamilon.A nootropic designed by the Russians. A simple bonding of niacin and gaba. There is plenty of research on this one, but almost all of it by the Russians, I’ll leave you to decide on its validity.
This is a good link:
http://www.smart-drugs.net/ias-depression.htm
As is:
And finally the most interesting in my view- Holy Basil.
Ocimum Sanctum otherwise known as holy Basil seems to be getting a reputation for working when nothing else does and doing so very quickly. I cannot find any studies but the anecdotal evidence seems very promising - after all that’s how iproniazid started!
Have a look at the following:
…http://channelcincinnati.com/cin/healthteam/stories/healthteam-naturalhealt…
and try the following for personal experiences of holy basil:
…http://groups.google.com/groups?q=holy+basil+depression&hl=en&1r=&ie=UTP-8&oe…
I hope that this is able to give some hope to us supposed difficult patients, but don’t tell your doc he’ll think you’re even more difficult!
All my best
Glenn
Posted by Gabbix2 on October 21, 2002, at 16:14:22
In reply to For all difficult patients, treatment resistants, posted by glenn on October 21, 2002, at 14:47:09
Hey Glenn
Thanks for the links.
Of course I won't really need them,
Afer all, i just act depressed to get attention....Miss borderline, refractory progressive
Gx2
Posted by Denise528 on October 22, 2002, at 8:01:48
In reply to For all difficult patients, treatment resistants, posted by glenn on October 21, 2002, at 14:47:09
Anyone interested in taking part in the nemifitide study, send a note to BSCHACKER1@aol.com, they'll send you a doc containing all the sites involved in the study.
If you do get to take part in the study then please keep us updated on how you get on.
Denise
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