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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by linkadge on July 3, 2002, at 14:19:29
I always thought that norepeniphrine would
only effect mood indirectly in that you
would have more energy/attentiveness and
therefore possibly feel more capable. If
norepenephrine directly affects mood, in what
way. What sorts of thoughts are altered or
enhanced by a proper norepenephrine ballance.All I know is that if I had taken Roboxatine
when I was depressed it would have only made
me worse. When I am depressed things are just
so sad. For instance I would cry uncontrollably
for hours because of a company that i'd never
heard of going out of buisness or somthing.
Norepinephrine at a time like this would only
make me feel more activated to take my life.
I think noradreneline enhancers should be never
be used in suicidal depression. What do others think ?
Posted by turalizz on July 3, 2002, at 14:46:42
In reply to Does Norepinephrine effect mood directlty, posted by linkadge on July 3, 2002, at 14:19:29
> I think noradreneline enhancers should be never
> be used in suicidal depression. What do others think ?Possibly you are right.
From my experience, I noticed an intensifying of my emotions on reboxetine. It was a blessing for me, because my depression was sort of a "masked", atypical one. As far as my depression was concerned, apathy was more likely than feeling sad, crying all the time etc.So, I presume such an intensifying of feelings might cause a disaster in most of the depressive cases.
My impression is that reboxetine and other noradrenergic AD's are useful in apathy and atypical sort of depression. My hypersomnia and difficulty waking up responded very well to noradrenergic AD's as well.
cem
Posted by cybercafe on July 3, 2002, at 16:20:02
In reply to Does Norepinephrine effect mood directlty, posted by linkadge on July 3, 2002, at 14:19:29
> way. What sorts of thoughts are altered or
> enhanced by a proper norepenephrine ballance.I understand that norepenephrine gives a sort of pleasurable reward for the continued performance of a certain action.... (possibly on the nucleus accumbens) ... whereas dopamine gives a sort of pleasurable reward for beginning the behaviour....
elsewhere i read lack of norepenephrine is responsible for:
depressed mood
decreased attention
decreased concentration
decreased working memory
decreased information processing
psychomotor retardation
fatigue
idiopathic hypersomnia
ummmm... but keep in mind that it's never really that simple. For example, norepenephrine receptors might cause the firing of a nerve that releases serotonin or dopamine. In a way, many different systems are connected, so it's hard to isolate primary and secondary effectscomments?
Posted by linkadge on July 3, 2002, at 20:34:48
In reply to Re: Does Norepinephrine effect mood directlty, posted by cybercafe on July 3, 2002, at 16:20:02
It seems kind of strange, but my
depression was so exasperted by
additional adreneline that I think
some sort of Norepenephrine blockade
would actually help. I am just learning
here, like most, but do beta blockers
block norepenephrine in the brain
or just in from reaching the heart
and stomach?
Posted by jay on July 4, 2002, at 0:07:46
In reply to Does Norepinephrine effect mood directlty, posted by linkadge on July 3, 2002, at 14:19:29
Like serotonin, (and any other brain chemicals), too much norepinephrine is not a good thing. This neurochemical seems responsible for our reactions to fear, and may play a part in anxiety and maybe even neurotic disorders.
But, just because a medication say's it increases a certain neurochemical doesn't mean more is better. The meds regulate the complicated transmission between brain cells, and one of the theories is that the change in a neurochemical level changes the receptors that these chemicals transmit with.
So, don't really believe the hype (especially in advertising) that a certain med "..increases neurochemical X". It is not the most important theraputic aspect of medication.
Best wishes,
Jay
Posted by cybercafe on July 4, 2002, at 0:28:21
In reply to Norepenephrine Blockade, posted by linkadge on July 3, 2002, at 20:34:48
> It seems kind of strange, but my
> depression was so exasperted by
> additional adreneline that I think
> some sort of Norepenephrine blockade
> would actually help. I am just learning
> here, like most, but do beta blockers
> block norepenephrine in the brain
> or just in from reaching the heart
> and stomach?Okay
1. adrenaline = Epenephrine, not norepenephrine
2. Beta blockers block noradrenergic beta receptors... beta receptors are primarily triggered by adrenaline, alpha receptors are the receptors primarily triggered by noradrenaline (norepenephrine)
blockade of beta-1 receptors is thought to cause depression, relief from anxiety, and bradycardia (slower heart beat)
This is the end of the thread.
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