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Dr. Bob is Robert Hsiung, MD,
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Posted by Margit on April 17, 2002, at 22:47:06
I am reading conflicting messages regarding Zyprexa and anticholinergic effects. Many say it doesn't have any, but I looked it up at the RXlist and the say "high affinity to muscarinic receptors (anticholingeric).
Who is right? This is important to me, since I am not supposed to take meds with high anticholinergic effects due to my acid reflux.
Thanks for any responses.
Margit
Posted by xjs7 on April 17, 2002, at 23:57:39
In reply to Zyprexa question, posted by Margit on April 17, 2002, at 22:47:06
Hi Margit,
Olanzapine [Zyprexa] has anticholinergic effects according to the prescribing information: "Olanzapine's antagonism of muscarinic M1-5 receptors may explain its anticholinergic effects." Another document I checked lists olanzapine's receptor blockade of M1 as high.
Due to your acid reflux problem, another drug might be better. Risperidone [Risperdal] and ziprasidone [Geodon] have no appreciable affinity for the cholinergic muscarinic receptor.
xjs7
This is the end of the thread.
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