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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by spike4848 on February 18, 2002, at 9:53:45
Hey Everyone,
Anyone use Bromocriptine or amantadine for depression?
Spike
Posted by Mr. Scott on February 18, 2002, at 18:17:10
In reply to Bromocriptine/Amantadine for depression, posted by spike4848 on February 18, 2002, at 9:53:45
Years ago when I wasn't such a an upstanding young man, and was withdrawing from prolonged Cocaine usage it was prescribed to me to help.
I found it helpful in making me more alert, and less agitated from Prozac. It was discontinued as I was able to remain clean for a few months(now over 5 years).
I have thought about trying to to get back on it.
I took 100mg TID.
Scott
Posted by TSA West on February 20, 2002, at 0:03:04
In reply to Bromocriptine/Amantadine for depression, posted by spike4848 on February 18, 2002, at 9:53:45
Dear Spike,
Here is some information on Bromocriptine in Depression:
Current Medical Research & Opinion. 8(3):150-3, 1982:
"A double-blind trial was carried out in 9 patients with endogenous depression to compare the effectiveness of bromocriptine (15 mg per day, 4 patients) with that of imipramine (75 mg per day, 5 patients) over a period of 10 weeks. The results of assessments using the Hamilton Rating Scale for Depression showed that both drugs produced comparable reduction in mean scores and there was no significant difference between the two treatment groups. Fewer patients had anticholinergic type side-effects on bromocriptine..."
A double-blind cross-over placebo-controlled trial of the effects of bromocriptine on psychomotor function, cognition, and mood in de novo patients with Parkinson's disease.
Behavioural Pharmacology. 6(1):81-91, 1995 January.
Department of Surgical Neurology and Clinical Neuropsychology, Morriston Hospital Swansea:"A review of the literature suggested that decreased emotional distress may have arisen through bromocriptine's action on neural circuits modulating mood. Some clinical implications of bromocriptine's effect on mood are mentioned...."
Department of Psychiatry, Hokkaido University School of Medicine. [Survey and treatment strategy of antidepressant-resistant depression].
Seishin Shinkeigaku Zasshi - Psychiatria et Neurologia Japonica. 98(5):329-42, 1996:"The addition of lithium, _bromocriptine_ or levothyroxine treatment were effective in the treatment of ARD (antidepressant-resistant depression). Levothyroxine were more effective in the treatment of the bipolar patients than the unipolar patients...."
Posted by OldSchool on February 20, 2002, at 15:55:15
In reply to Bromocriptine/Amantadine for depression, posted by spike4848 on February 18, 2002, at 9:53:45
I recently tried Amantadine with Zoloft. It was the first and only dopamine agonist Id ever tried. I was also taking the Amantadine for EPS and it definitely helped the EPS. It was different, thats for sure. It did activate the Zoloft, however at the same time left me so dizzy, confused and created so much somnolence I couldnt tolerate it. It also made my muscles stiffen up real bad, but in a different kind of way than EPS does. Its hard to describe, but the Amantadine loosened up things but at the same time created new stiffness...I guess some kind of acute dyskinesia. I understand all these dopamine agonist parkinsons drugs can create dyskinesias.
I found physically it made me feel much better. I didnt feel "tight" all the time, it loosened up my chest muscles and breathing, my sleep improved on it a lot and it also really increased my sex drive A LOT. I guess what Im trying to say is that physically the Amantadine made me feel MUCH better, but mentally it left me super dizzy and made me confused (psychotic?) feeling although I wonder if that would have gone away after a while.
Another thing about the Amantadine was that it did make me feel happier.Im thinking about trying the Amantadine again soon. I liked it a lot in some respects.
Id also tried Ritalin with Prozac before and the Amantadine was a gazillion times stronger than Ritalin. Ritalin increased my concentration a lot and made me be able to think more clearly.
BTW, if it was me Id try Mirapex vs. bromocriptine for TRD. Also, remember that all of these direct dopamine agonists can cause psychosis in people...thats pure dopamine dude.
Old School
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