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Dr. Bob is Robert Hsiung, MD,
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Posted by Michael D on February 13, 2002, at 11:10:07
Is it possible that the reason why SSRI's seem to work for the first few days after I have an increase in dose, is due to the seratonin, dopamine and norepinephrine reacting at different rates?
Michael D
Posted by Ritch on February 13, 2002, at 12:51:52
In reply to dopamine and norepinephrine question, posted by Michael D on February 13, 2002, at 11:10:07
> Is it possible that the reason why SSRI's seem to work for the first few days after I have an increase in dose, is due to the seratonin, dopamine and norepinephrine reacting at different rates?
>
> Michael DI suppose so in some round about way. Or it could simply be that everytime you increase the dose of SSRI your body has to "readjust" yet again. Perhaps the process of "readjustment" to a stimulus (dose increase) is the actual antidepressant mechanism (perhaps the "changing rates" you spoke of). That is kind of scary, though. It might explain SSRI "poop-out". That might also explain why continually switching antidepressants may work for some people to maintain antidepressant response. Obviously those processes need to be looked into closer (they probably are).
Mitch
Posted by Bill L on February 13, 2002, at 13:14:02
In reply to dopamine and norepinephrine question, posted by Michael D on February 13, 2002, at 11:10:07
How long have you been on the 60 mg of Celexa? You should give it at least 6 weeks. If that doesn't help you could go higher than 60 mg (if your doctor ok's it) or augment as Petters suggested. Lots of people benefit from adding lithium or Wellbutrin.
> Is it possible that the reason why SSRI's seem to work for the first few days after I have an increase in dose, is due to the seratonin, dopamine and norepinephrine reacting at different rates?
>
> Michael D
This is the end of the thread.
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