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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 2 of 2. This is the beginning of the thread.
Posted by Dr. Bob on February 13, 2002, at 1:51:38
[Posted by Gray on February 11, 2002, at 0:33:09]
> Hi,
> I have really enjoyed reading the posts at this site. I have found the information invaluable. The
> people that post here are well-read and have done their
> homework when it comes to pharmacology. This is the
> most sophisticated chat room concerning psycology and
> drug discourse that I have found on the net.The
> discussions about foriegn drugs have been informative.
> I have struggled with treatment resistant depression
> for many years. It was't until I started reading posts
> here that I finally figured out that I had a problem
> with low levels of dopamine. When I read about Amineptine here and its effect on dopamine a lightbulb
> lit up. What I don't understand is why there is so
> little talk of dopamine in most of the antidepressent
> literature. I recently changed from Reboxetine to
> Effexor XR and then added Zyprexa to the Effexor with
> very good results. I learned about Zyprexa at this site. JohnL's knowledge has been especially astute.
> AndrewB's 'amisulpride answers' is excellent. SalArmy4Me has provided lots of great input. For the
> first time in years I'm beating this ugly beast.
> I have found that Dexedrine has been an excellent
> jumpstarter for my antidepressents and accelerates
> theraputic effect. Dex speeds up body metabolism(heart
> rate, circulation, brain funtion, acuity, eliminations,
> ect.). If one suffers from lethargy as I often have,
> the Dex gets some of these bodily systems back on line.
> I am interested in discussing dopamine functions
> further. They seem to be very complex. As I understand
> it there are basically five dopamine pathways that we
> know about, two of which are in the limbic area of the
> brain. Also does anyone know the meaning of the following terms(abbreviations): Ki(nM)
> 5HT
> Ki NE/ Ki 5HT
> Thank you for your input. GRAY
Posted by Ritch on February 13, 2002, at 11:03:39
In reply to Treatment resistant depression « Gray, posted by Dr. Bob on February 13, 2002, at 1:51:38
> > I am interested in discussing dopamine functions
> > further. They seem to be very complex. As I understand
> > it there are basically five dopamine pathways that we
> > know about, two of which are in the limbic area of the
> > brain. Also does anyone know the meaning of the following terms(abbreviations): Ki(nM)
> > 5HT
> > Ki NE/ Ki 5HT
> > Thank you for your input. GRAY
The abbreviations...Ok let's see:
5HT --5,hydroxytryptophan -- (serotonin)
Ki -- Now that one took a little looking about!
But, is this right? (constant of inhibition)
nM -- nanomolar -- a mole is Avogadro's number, and nano is a "millionth"-so the number of molecules in nM would be in millionths of a mole.So....
The lower the Ki(nM) the higher the affinity of the substance to target receptors, enzymes, transporters, etc.So...
A statement like Ki NE/Ki 5-HT would express
the relative ability of antidepressant (i.e.) to block the reuptake transporters associated with NE and 5-HT receptors. A low number would show a definite preference for the NE transorters, while a very high number would show preference for the 5-HT (serotonin) transporters.So...
A medication like desipramine should have a fairly low number, and a medication like citalopram should have a very high number.I think I created some new dopamine connections in my brain just trying to sort it out. That's it! School isn't about making money, it is to keep you from being depressed.:)
Mitch
This is the end of the thread.
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