Psycho-Babble Medication Thread 90576

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which anti-psychotic is less likely to cause eps

Posted by borderliner21 on January 17, 2002, at 1:15:54

I cannot tolerate meds that cause inner restlessness. What would be the best anti-psychotic and the med dosage that is least likely to produce eps. thanks

2 atypicals » borderliner21

Posted by TSA West on January 17, 2002, at 21:17:10

In reply to which anti-psychotic is less likely to cause eps, posted by borderliner21 on January 17, 2002, at 1:15:54

I have a decent answer to your question, and your concern about EPS is understandable.

_Olanzapine_

Olanzapine vs. Risperidone (http://www.vh.org/Providers/Conferences/CPS/04.html#OLANZAPINE):

"Finally, the adverse drug reactions favored olanzapine in that fewer patients experience extrapyramidal side effects, sexual dysfunction, and drooling."

_Quetiapine_

(http://www.vh.org/Providers/Conferences/CPS/04.html#QUETIAPINE):

"There was no difference between quetiapine and placebo treatment groups in the incidence of EPS in 3 placebo-controlled clinical trials using variable doses of quetiapine."

There was no difference between quetiapine and placebo treatment groups in the incidence of EPSE in 3 placebo-controlled clinical trials using variable doses of quetiapine.

Re: which anti-psychotic is less likely to cause eps

Posted by OldSchool on January 23, 2002, at 21:06:10

In reply to which anti-psychotic is less likely to cause eps, posted by borderliner21 on January 17, 2002, at 1:15:54

> I cannot tolerate meds that cause inner restlessness. What would be the best anti-psychotic and the med dosage that is least likely to produce eps. thanks

All of them can cause EPS. Clozapin is supposed to be the safest anti-psychotic as far as not causing movement disorders like EPS. However even with clozapine there is some potential for EPS. Zyprexa is pretty safe. But again, no anti-psychotic carries with it 0% chance of developing EPS. All of them can, even the modern atypical antipsychotics.

Clozapine is your best bet though, if you really want to avoid EPS.

Old School

Re: which anti-psychotic is less likely to cause eps

Posted by Blue Cheer 1 on January 25, 2002, at 6:11:53

In reply to Re: which anti-psychotic is less likely to cause eps, posted by OldSchool on January 23, 2002, at 21:06:10

> > I cannot tolerate meds that cause inner restlessness. What would be the best anti-psychotic and the med dosage that is least likely to produce eps. thanks
>
>
> All of them can cause EPS. Clozapin is supposed to be the safest anti-psychotic as far as not causing movement disorders like EPS. However even with clozapine there is some potential for EPS. Zyprexa is pretty safe. But again, no anti-psychotic carries with it 0% chance of developing EPS. All of them can, even the modern atypical antipsychotics.
>
> Clozapine is your best bet though, if you really want to avoid EPS.
>
> Old School

Clozapine is no longer considered first-line therapy because of its severe side effects. Zyprexa, Seroquel, Risperdal, and Geodon are equally efficacious, have a better side-effect profile, and cause minimal rates of EPS and TD.

Blue

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