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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by JohnX2 on November 19, 2001, at 13:15:15
Does wellbutrin inhibit the liver enzyme cyp-450 2d6?
I've seen references that go both ways.thanks for any feedback,
john
Posted by SLS on November 19, 2001, at 18:27:38
In reply to Does Wellbutrin inhibit cyp450-2d6, posted by JohnX2 on November 19, 2001, at 13:15:15
>
> Does wellbutrin inhibit the liver enzyme cyp-450 2d6?
> I've seen references that go both ways.
>
> thanks for any feedback,
> john
Hi John.Have you seen this site yet?
http://medicine.iupui.edu/flockhart/
- Scott
Posted by SLS on November 19, 2001, at 18:43:45
In reply to Re: Does Wellbutrin inhibit cyp450-2d6, posted by SLS on November 19, 2001, at 18:27:38
> >
> > Does wellbutrin inhibit the liver enzyme cyp-450 2d6?
> > I've seen references that go both ways.
> >
> > thanks for any feedback,
> > john
>
>
> Hi John.
>
> Have you seen this site yet?
>
> http://medicine.iupui.edu/flockhart/
>
>
> - Scott
I see that this webpage does not include information for bupropion.I found this:
"Bupropion inhibits metabolism by cytochrome P450 2D6. Caution is advised when medicinal products metabolised by this enzyme are administered concomitantly."
http://www.ash.org.uk/html/cessation/zybanspc0501.pdf
Zyban TM (Bupropion hydrochloride)
SUMMARY OF PRODUCT CHARACTERISTICS
May 2001 (provided by GlaxoSmithKline)
Posted by SLS on November 19, 2001, at 18:44:42
In reply to Re: Does Wellbutrin inhibit cyp450-2d6 » SLS, posted by SLS on November 19, 2001, at 18:43:45
Posted by JohnX2 on November 19, 2001, at 22:30:21
In reply to Re: Does Wellbutrin inhibit cyp450-2d6 » SLS, posted by SLS on November 19, 2001, at 18:43:45
I have a link to that table you pointed to,
I usually use it to look for drug interactions.
It still seems as though I see conflicting reports
on Wellbutrin and cyp 450-2d6. The latest pdr
showed it inhibited the enzme but other studies
showed little interactions. Maybe this data
is more recent.regards,
john
> > >
> > > Does wellbutrin inhibit the liver enzyme cyp-450 2d6?
> > > I've seen references that go both ways.
> > >
> > > thanks for any feedback,
> > > john
> >
> >
> > Hi John.
> >
> > Have you seen this site yet?
> >
> > http://medicine.iupui.edu/flockhart/
> >
> >
> > - Scott
>
>
> I see that this webpage does not include information for bupropion.
>
> I found this:
>
> "Bupropion inhibits metabolism by cytochrome P450 2D6. Caution is advised when medicinal products metabolised by this enzyme are administered concomitantly."
>
> http://www.ash.org.uk/html/cessation/zybanspc0501.pdf
>
> Zyban TM (Bupropion hydrochloride)
> SUMMARY OF PRODUCT CHARACTERISTICS
> May 2001 (provided by GlaxoSmithKline)
Posted by Sunnely on November 19, 2001, at 22:35:29
In reply to Does Wellbutrin inhibit cyp450-2d6, posted by JohnX2 on November 19, 2001, at 13:15:15
Yes. The primary concern will be the common practice of combining antidepressants in particular, Wellbutrin with a tricyclic antidepressant (TCA) such as nortriptyline, imipramine, and desipramine. This could lead to dramatic increase in TCA blood level, in turn leading to TCA toxicity such as lethargy/agitation, confusion, delirium (central anticholinergic toxicity), and even cardiac toxicity.
You should be aware that Wellbutrin SR and Zyban have exactly similar pharmacokinetic properties.
>
> Does wellbutrin inhibit the liver enzyme cyp-450 2d6?
> I've seen references that go both ways.
>
> thanks for any feedback,
> john
This is the end of the thread.
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