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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by Jackster on October 1, 2001, at 3:57:41
Does anyone know of a web page that shows the spectrum of tricyclic antidepressants - i.e. what they are used for, which neurotransmitter they mainly target, and what their side effects are? For example, I know clomipramine is mainly serotonin reuptake inhibiting (and is making me really irritable) and amitriptaline is less serotonin and more of the other two (which I can't remember the names of). I've looked but can't seem to find anything that does this.
Thanks
Jackie
Posted by Elizabeth on October 1, 2001, at 14:53:21
In reply to Tricyclic spectrum?, posted by Jackster on October 1, 2001, at 3:57:41
> Does anyone know of a web page that shows the spectrum of tricyclic antidepressants - i.e. what they are used for, which neurotransmitter they mainly target, and what their side effects are?
Not a web page off the top of my head, but I can give you a list if you'd like. The ones I am most familiar with are the ones available in the U.S., of which there are ten.
Tricyclics in general inhibit reuptake of monoamines, mainly norepinephrine and serotonin. (Dopamine is not generally affected to a significant degree.) They have cardiac side effects and can cause serious problems for people with certain types of cardiovascular disease. They also have "anticholinergic" side effects such as dry mouth and constipation, and some other side effects due to blockade of other receptor types.
Like I said, I can give you more details if you like, although I don't know of any particular web site that has the info (which is not entirely agreed-upon even by "experts," in any case).
-elizabeth
Posted by ChrisK on October 2, 2001, at 4:38:10
In reply to Tricyclic spectrum?, posted by Jackster on October 1, 2001, at 3:57:41
It's not all nice and neat on one page buit all of the info you want is available at http://www.rxlist.com/ .Just type in the drug name in the search window. You will get a list of possible matches - click on the one nearest to what your looking for. It will then take you to a page describing the drug in question. Click on the tab that says "Clinical Pharmacology" at the top of the box. This will give you the info you are looking for as to how it is believed that the med works. You can also find most all of the information available in the PDR on the other tabs.
Hope this helps,
Chris
Posted by Mitch on October 2, 2001, at 10:10:09
In reply to Tricyclic spectrum?, posted by Jackster on October 1, 2001, at 3:57:41
> Does anyone know of a web page that shows the spectrum of tricyclic antidepressants - i.e. what they are used for, which neurotransmitter they mainly target, and what their side effects are? For example, I know clomipramine is mainly serotonin reuptake inhibiting (and is making me really irritable) and amitriptaline is less serotonin and more of the other two (which I can't remember the names of). I've looked but can't seem to find anything that does this.
>
> Thanks
> JackieI came across a "transporter affinity" profile sheet once at my pdoc's. As far as TCA's go (from what I remember) the one at the top has the most affinity for the NE transporter and the ones toward the bottom increasing affinity for 5-HT transporters:
1) Desipramine
2) Nortripytline
3) Doxepin
4) Amitriptyline
5) Imipramine
6) ClomipramineThere are a few other TCA's, but I didn't see them listed.
Posted by Jackster on October 2, 2001, at 16:07:22
In reply to Re: Tricyclic spectrum?, posted by Mitch on October 2, 2001, at 10:10:09
> > Does anyone know of a web page that shows the spectrum of tricyclic antidepressants - i.e. what they are used for, which neurotransmitter they mainly target, and what their side effects are? For example, I know clomipramine is mainly serotonin reuptake inhibiting (and is making me really irritable) and amitriptaline is less serotonin and more of the other two (which I can't remember the names of). I've looked but can't seem to find anything that does this.
> >
> > Thanks
> > Jackie
>
> I came across a "transporter affinity" profile sheet once at my pdoc's. As far as TCA's go (from what I remember) the one at the top has the most affinity for the NE transporter and the ones toward the bottom increasing affinity for 5-HT transporters:
> 1) Desipramine
> 2) Nortripytline
> 3) Doxepin
> 4) Amitriptyline
> 5) Imipramine
> 6) Clomipramine
>
> There are a few other TCA's, but I didn't see them listed.
Thanks Mitch - that was exactly what I was looking for. And don't worry - it's not for self medicating, but so I am informed for when I see my PDoc next.Jackie
This is the end of the thread.
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