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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 9 of 9. This is the beginning of the thread.
Posted by Mr. Scott on March 18, 2001, at 20:18:40
Does anyone have any comparitive experience here? Which of these two drugs are better?
Scott
Posted by krista on June 14, 2001, at 12:07:15
In reply to Adafrinil vs. Modafinil (Provigil), posted by Mr. Scott on March 18, 2001, at 20:18:40
> Does anyone have any comparitive experience here? Which of these two drugs are better?
>
> ScottI would like to know also as I want to try one or the other. And modafinal is sooo expensive adafrinil is not!
Posted by JohnL on June 16, 2001, at 4:35:40
In reply to Re: Adafrinil vs. Modafinil (Provigil), posted by krista on June 14, 2001, at 12:07:15
Hi,
I have personal experience with both of these meds. For me Adrafinil is far superior to Modafinil. It's strange because they are almost identical in molecular diagrams, but wow are they different in real life. Adrafinil makes me feel motivated and interested, without feeling like I'm speeding on a stimulant, and it's great. Modafinil on the other hand was weird. For example, it would give me a lot of pep for a couple hours, but then was followed by profound tiredness and exhaustion. And it did nothing for my mood or motivation. Very strange stimulant. For some people it's great, but for me I find Adrafinil wonderful. Also much cheaper. I have no side effects.I have been taking Adrafinil for quite a few months now. I am on the minimum dose and there is no sign of poopout or tolerance at all. My liver and blood test the other day came back perfectly normal.
When I started Adrafinil I felt a nice pep during the first few days, which then vanished, but then returned again a bit slower over time. It really took 3 to 4 weeks for it to really kick in. Literature says it takes weeks to fully work, though I felt it almost immediately.
I think Adrafinil is best suited for those types of depression characterized by dullness, lack of motivation, lack of pleasure, lack of interest. Also well suited for the negative symptoms of schizophrenia. I'm not sure if Adrafinil is good for the type of depression characterized by crying and despair. One cool thing about Adrafinil that is different than other meds is that it can provide benefits even to someone who isn't depressed. Over time Adrafinil can make one more talkative, more outgoing, more involved, and more socially comfortable and confident.
Disclaimer though...like all meds it won't work for everyone. Also, I take minimum doses of Prozac during the day and Zyprexa at night. So I can't give all the credit to Adrafinil, though it is a major player. I sink into dullness without it.
John> > Does anyone have any comparitive experience here? Which of these two drugs are better?
> >
> > Scott
>
> I would like to know also as I want to try one or the other. And modafinal is sooo expensive adafrinil is not!
Posted by Mitch on June 16, 2001, at 10:10:26
In reply to Re: Adafrinil vs. Modafinil (Provigil), posted by JohnL on June 16, 2001, at 4:35:40
JohnL,
Is Adafranil available in the U.S. right now? I see my pdoc next week and I am going to bring it up for sure. I go into a seasonal bipolar "anergic" major depressive episode anytime in the next few weeks that will last for about two months and I am going to need something "extra".
Mitch
> Hi,
> I have personal experience with both of these meds. For me Adrafinil is far superior to Modafinil. It's strange because they are almost identical in molecular diagrams, but wow are they different in real life. Adrafinil makes me feel motivated and interested, without feeling like I'm speeding on a stimulant, and it's great. Modafinil on the other hand was weird. For example, it would give me a lot of pep for a couple hours, but then was followed by profound tiredness and exhaustion. And it did nothing for my mood or motivation. Very strange stimulant. For some people it's great, but for me I find Adrafinil wonderful. Also much cheaper. I have no side effects.
>
> I have been taking Adrafinil for quite a few months now. I am on the minimum dose and there is no sign of poopout or tolerance at all. My liver and blood test the other day came back perfectly normal.
>
> When I started Adrafinil I felt a nice pep during the first few days, which then vanished, but then returned again a bit slower over time. It really took 3 to 4 weeks for it to really kick in. Literature says it takes weeks to fully work, though I felt it almost immediately.
>
> I think Adrafinil is best suited for those types of depression characterized by dullness, lack of motivation, lack of pleasure, lack of interest. Also well suited for the negative symptoms of schizophrenia. I'm not sure if Adrafinil is good for the type of depression characterized by crying and despair. One cool thing about Adrafinil that is different than other meds is that it can provide benefits even to someone who isn't depressed. Over time Adrafinil can make one more talkative, more outgoing, more involved, and more socially comfortable and confident.
>
> Disclaimer though...like all meds it won't work for everyone. Also, I take minimum doses of Prozac during the day and Zyprexa at night. So I can't give all the credit to Adrafinil, though it is a major player. I sink into dullness without it.
> John
>
> > > Does anyone have any comparitive experience here? Which of these two drugs are better?
> > >
> > > Scott
> >
> > I would like to know also as I want to try one or the other. And modafinal is sooo expensive adafrinil is not!
Posted by Mitch on June 16, 2001, at 10:36:37
In reply to Re: Adafrinil vs. Modafinil (Provigil), posted by JohnL on June 16, 2001, at 4:35:40
JohnL,
Thanks for the info about Adafrinil. I found some other posts below where you mentioned that it wasn't available in the US. BUMMER. I know that Reboxetine isn't here either, and tamoxetine isn't going to be approved yet, so much for the FDA! It seems almost conspiratorial how they are holding up the newer (developed outside the US) selective NRI meds as long as they can so *we* can come up with something to compete with it. Go figure.
Mitch
Posted by krista on June 16, 2001, at 13:33:48
In reply to Re: Adafrinil NOT in the US-sorry » JohnL, posted by Mitch on June 16, 2001, at 10:36:37
I tried Roboextine, had to order it from Canada. You my try ordring Adafranil from Cananda. Insurance may not cover it but i think it's relatively cheap, I heard someone say $25
I think most doctors are able to fax prescriptions out for you to Canada. It usually took them 4 days to ship the drug to me.krista
p.S Roboxetine worked horribly for me!
Posted by Mitch on June 16, 2001, at 14:44:56
In reply to Re: Adafrinil NOT in the US-sorry, posted by krista on June 16, 2001, at 13:33:48
> I tried Roboextine, had to order it from Canada. You my try ordring Adafranil from Cananda. Insurance may not cover it but i think it's relatively cheap, I heard someone say $25
> I think most doctors are able to fax prescriptions out for you to Canada. It usually took them 4 days to ship the drug to me.
>
> krista
>
> p.S Roboxetine worked horribly for me!Thanks Krista!
I don't think that my pdoc will go out on a limb for me that far. Especially not certain of knowing how I will probably react to it. I want to try something new that is going to act on norepi, but there isn't anything new HERE of course. It looks like probably Nortriptyline again-ok, but it hits too many receptors. I will ask though.
thanks,
Mitch
Posted by blackjack on June 17, 2001, at 14:13:20
In reply to Re: Adafrinil vs. Modafinil (Provigil), posted by krista on June 14, 2001, at 12:07:15
> > Does anyone have any comparitive experience here? Which of these two drugs are better?
> >
> > Scott
>
> I would like to know also as I want to try one or the other. And modafinal is sooo expensive adafrinil is not!The primary difference (other than the fact that Adrafinil isn't FDA approved) is that Modafinil is significantly less hepatoxic. Adrafinil CAN cause liver problems in some people (tho not most) and Modafinil is much less likely to do so. That is the main reason Modofinil is FDA-approved an Adrafinil isn't, tho I wouldn't be surprised if there was business or politics involved too.
Posted by dr. austin on January 1, 2005, at 19:43:49
In reply to Re: Adafrinil vs. Modafinil (Provigil), posted by JohnL on June 16, 2001, at 4:35:40
Is adafrinil an mao inhibitor?
This is the end of the thread.
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