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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by PaulB on April 12, 2001, at 17:56:16
Because the benzodiazepines are unselective for GABA receptors and stimulate gabergic receptors involved in reducing anxiety and panic as well as those receptors involved in sedation I was wondering whether benzodiazepines could be augmented with selective GABA antagonists to allow a person to continue to experience the anxiolytic effect of the drug but eliminate the amnesic and sedative effects that the benzodiazepines have? Can you mention any that are available?
Posted by SLS on April 13, 2001, at 10:36:37
In reply to Richelson-GABA antagonists, posted by PaulB on April 12, 2001, at 17:56:16
> Because the benzodiazepines are unselective for GABA receptors and stimulate gabergic receptors involved in reducing anxiety and panic as well as those receptors involved in sedation I was wondering whether benzodiazepines could be augmented with selective GABA antagonists to allow a person to continue to experience the anxiolytic effect of the drug but eliminate the amnesic and sedative effects that the benzodiazepines have? Can you mention any that are available?
I think I heard something about the designing of benzodiazepines to be selective for, or specific to, one of the several *benzodiazepine* receptors. Supposedly, the result is a drug that retains its anxiolytic properties without producing tolerance or sedation. I don’t remember the details very well.
- Scott
Posted by Dr. Bob on April 17, 2001, at 10:38:00
In reply to Richelson-GABA antagonists, posted by PaulB on April 12, 2001, at 17:56:16
> Because the benzodiazepines are unselective for GABA receptors and stimulate gabergic receptors involved in reducing anxiety and panic as well as those receptors involved in sedation I was wondering whether benzodiazepines could be augmented with selective GABA antagonists to allow a person to continue to experience the anxiolytic effect of the drug but eliminate the amnesic and sedative effects that the benzodiazepines have? Can you mention any that are available?
Great question, but no answer at this time. I am not aware of any selective antagonists for the benzodiazepine binding site that are clinically available or are in clinical development.
Posted by SLS on April 17, 2001, at 13:58:36
In reply to Richelson-GABA antagonists, posted by PaulB on April 12, 2001, at 17:56:16
I tried to go back and find where I had seen the information:
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Staying alert to new anti-anxiety drugs
http://www.nature.com/neuro/press_release/nn0600.html
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I would like to see the previous article that was refered to. If you can get the full text, please post some of its salient points.
Thanks.
- Scott
This is the end of the thread.
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