Psycho-Babble Medication Thread 53626

Shown: posts 1 to 4 of 4. This is the beginning of the thread.

 

Mirapex is a gift from God!

Posted by SalArmy4me on February 9, 2001, at 19:20:29

Mirapex is a dopamine agonist that is most often used for Parkinson's Disease. But, it has been shown in two studies to have antidepressant properties in non-Parkinson's patients.
First, the background: I have treatment-resistant depression with painful flashbacks and Obsessive-Compulsive Disorder.
It started working for me in a little less than a week (possibly because I got up to 6 mg per day in two days' time)! I found out that it needs to be taken about every 5 hours, otherwise I relapse. I have no side-effects from it (thank God).
Studies on Medline:
2. Pramipexole augmentation in the treatment of unipolar and bipolar depression: a retrospective chart review Ann Clin Psychiatry. 2000 Sep;12(3):137-40. [Record as supplied by publisher] PMID: 10984002
3:
Maj J, Rogoz Z.
Related Articles
Synergistic effect of pramipexole and sertraline in the forced swimming test. Pol J Pharmacol. 1999 Nov-Dec;51(6):471-5.
PMID: 10817524
4: Corrigan MH, Denahan AQ, Wright CE, Ragual RJ, Evans DL. Related Articles Comparison of pramipexole, fluoxetine, and placebo in patients with major depression. Depress Anxiety. 2000;11(2):58-65. PMID: 10812530
5: DeBattista C, Solvason HB, Breen JA, Schatzberg AF. Related Articles Pramipexole augmentation of a selective serotonin reuptake inhibitor in the treatment of depression. J Clin Psychopharmacol. 2000 Apr;20(2):274-5. No abstract available. PMID: 10770475
6:
Goldberg JF, Frye MA, Dunn RT.
Related Articles
Pramipexole in refractory bipolar depression.
Am J Psychiatry. 1999 May;156(5):798. No abstract available.
PMID: 10327923
7:
Bennett JP, Piercey MF.
Related Articles
Pramipexole--a new dopamine agonist for the treatment of Parkinson's disease. J Neurol Sci. 1999 Feb 1;163(1):25-31. Review.
PMID: 10223406
8: Piercey MF. Related Articles Pharmacology of pramipexole, a dopamine D3-preferring agonist useful in treating Parkinson's disease. Clin Neuropharmacol. 1998 May-Jun;21(3):141-51. Review. PMID: 9617505
9:
Willner P.
Related Articles
The mesolimbic dopamine system as a target for rapid antidepressant action. Int Clin Psychopharmacol. 1997 Jul;12 Suppl 3:S7-14. Review.
PMID: 9347387

 

Re: Mirapex is a gift from God!

Posted by J. Lester on February 9, 2001, at 20:30:43

In reply to Mirapex is a gift from God!, posted by SalArmy4me on February 9, 2001, at 19:20:29

> Mirapex is a dopamine agonist that is most often used for Parkinson's Disease. But, it has been shown in two studies to have antidepressant properties in non-Parkinson's patients.
> First, the background: I have treatment-resistant depression with painful flashbacks and Obsessive-Compulsive Disorder.
> It started working for me in a little less than a week (possibly because I got up to 6 mg per day in two days' time)! I found out that it needs to be taken about every 5 hours, otherwise I relapse. I have no side-effects from it (thank God).
> Studies on Medline:

I am glad it is working for you. I took around 0.5 mg 3 times a day for 10 days and it made me nauseated. I am also not sure if I felt any difference. Anyway I will try it again later with a larger dosage.
J.L.

 

Re: Mirapex is a gift from God! » SalArmy4me

Posted by natg on February 10, 2001, at 0:07:52

In reply to Mirapex is a gift from God!, posted by SalArmy4me on February 9, 2001, at 19:20:29

Hi,
I, too, have been taking mirapex for several months now and it has been the best thing that's happened to me.
you are very lucky that you have no side- effects from it. I take 3.5 a day and at this dose I feel very nauseated.
do you take mirapex with food? have you experienced any weight gain? do you take any other meds?

Thanks for your post. I'm thrilled that mirapex is working for you.

All the best,
Nat


######
> Mirapex is a dopamine agonist that is most often used for Parkinson's Disease. But, it has been shown in two studies to have antidepressant properties in non-Parkinson's patients.
> First, the background: I have treatment-resistant depression with painful flashbacks and Obsessive-Compulsive Disorder.
> It started working for me in a little less than a week (possibly because I got up to 6 mg per day in two days' time)! I found out that it needs to be taken about every 5 hours, otherwise I relapse. I have no side-effects from it (thank God).
> Studies on Medline:
> 2. Pramipexole augmentation in the treatment of unipolar and bipolar depression: a retrospective chart review Ann Clin Psychiatry. 2000 Sep;12(3):137-40. [Record as supplied by publisher] PMID: 10984002
> 3:
> Maj J, Rogoz Z.
> Related Articles
> Synergistic effect of pramipexole and sertraline in the forced swimming test. Pol J Pharmacol. 1999 Nov-Dec;51(6):471-5.
> PMID: 10817524
> 4: Corrigan MH, Denahan AQ, Wright CE, Ragual RJ, Evans DL. Related Articles Comparison of pramipexole, fluoxetine, and placebo in patients with major depression. Depress Anxiety. 2000;11(2):58-65. PMID: 10812530
> 5: DeBattista C, Solvason HB, Breen JA, Schatzberg AF. Related Articles Pramipexole augmentation of a selective serotonin reuptake inhibitor in the treatment of depression. J Clin Psychopharmacol. 2000 Apr;20(2):274-5. No abstract available. PMID: 10770475
> 6:
> Goldberg JF, Frye MA, Dunn RT.
> Related Articles
> Pramipexole in refractory bipolar depression.
> Am J Psychiatry. 1999 May;156(5):798. No abstract available.
> PMID: 10327923
> 7:
> Bennett JP, Piercey MF.
> Related Articles
> Pramipexole--a new dopamine agonist for the treatment of Parkinson's disease. J Neurol Sci. 1999 Feb 1;163(1):25-31. Review.
> PMID: 10223406
> 8: Piercey MF. Related Articles Pharmacology of pramipexole, a dopamine D3-preferring agonist useful in treating Parkinson's disease. Clin Neuropharmacol. 1998 May-Jun;21(3):141-51. Review. PMID: 9617505
> 9:
> Willner P.
> Related Articles
> The mesolimbic dopamine system as a target for rapid antidepressant action. Int Clin Psychopharmacol. 1997 Jul;12 Suppl 3:S7-14. Review.
> PMID: 9347387

 

Re: Mirapex is a gift from God!

Posted by SalArmy4me on February 10, 2001, at 5:52:47

In reply to Re: Mirapex is a gift from God! » SalArmy4me, posted by natg on February 10, 2001, at 0:07:52

I take upwards of 6 mg Mirapex per day and still have no side-effects. I don't have to take it with food. As far as weight gain, I haven't been on it long enough to notice that (only 2 weeks). The Mirapex works to a certain extent for my severe depression--maybe 25%--and it gives me hope that I might not have to go in for ECT.

But I am wondering if there are any cognitive side-effects from Mirapex that are so small that I would hardly notice them. Does that make sense?

You're not going to believe this: I also take mirtazapine, lamotrigine, venlafaxine XR, buproprion, buspirone, and pindolol.

I am still clinically depressed, though. :(

How much has the Mirapex alleviated your depression? 50%? 75%? I'm curious.

> Hi,
> I, too, have been taking mirapex for several months now and it has been the best thing that's happened to me.
> you are very lucky that you have no side- effects from it. I take 3.5 a day and at this dose I feel very nauseated.
> do you take mirapex with food? have you experienced any weight gain? do you take any other meds?
>

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