Psycho-Babble Medication Thread 37626

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Why Paxil and Buspar?

Posted by Billb on June 17, 2000, at 9:04:28

My doc. prescribed me paxil and buspar for social anxiety and depression. Do these drugs complement each other? Do they work differently? Any tips would be appreciated. Billb.

Re: Why Paxil and Buspar?

Posted by Cam W. on June 17, 2000, at 11:39:35

In reply to Why Paxil and Buspar?, posted by Billb on June 17, 2000, at 9:04:28

Bill - Sorry, I forgot about your earlier question on this. I have been giving it some thought, though. I think that there would have to be some synergistic activity between these two compounds. While Paxil would increase serotonin transmission in a general way (ie throughout the brain), BuSpar regulates serotonergic transmission through a specific serotonin receptor (5HT-1A receptor, where it acts to both block and stimulate the receptor - ie acts as a mixed antagonist/agonist). I believe it is this action which is thought to more directly decreases anxiety (not positive - BuSpar's mechanism of action in anxiety has not been determined, yet). Therefore, Paxil and BuSpar probably complement each other.

Hope this helps - Cam

Thanks Cam!

Posted by Billb on June 18, 2000, at 8:34:07

In reply to Re: Why Paxil and Buspar?, posted by Cam W. on June 17, 2000, at 11:39:35

>
> Bill - Sorry, I forgot about your earlier question on this. I have been giving it some thought, though. I think that there would have to be some synergistic activity between these two compounds. While Paxil would increase serotonin transmission in a general way (ie throughout the brain), BuSpar regulates serotonergic transmission through a specific serotonin receptor (5HT-1A receptor, where it acts to both block and stimulate the receptor - ie acts as a mixed antagonist/agonist). I believe it is this action which is thought to more directly decreases anxiety (not positive - BuSpar's mechanism of action in anxiety has not been determined, yet). Therefore, Paxil and BuSpar probably complement each other.
>
> Hope this helps - Cam

Thanks Cam. I appreciate your response. You seem very knowledgeble. Billb

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