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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by Mark on December 9, 1999, at 17:54:58
Can Nardil, or any other MAOI, be taken all at once (entire daily dosage at once). Why is it necessary to split up the dose? Do MAOIs have short half-lives like the benzos, or is it due to blood pressure reasons?
Posted by JIM on December 10, 1999, at 0:31:15
In reply to Nardil and MAOI dosages, posted by Mark on December 9, 1999, at 17:54:58
> Can Nardil, or any other MAOI, be taken all at once (entire daily dosage at once). Why is it necessary to split up the dose? Do MAOIs have short half-lives like the benzos, or is it due to blood pressure reasons?
>
> Nardil can be taken all at once either first thing in the morning or at bedtime. Parnate is best taken in divided doses, morning and early afternoon. MAOIs due work better when taken in divided doses. They do tend to have short half-lives. I take nardil in the morning so as to interfer with sleep as little as possible.
Posted by Elizabeth on December 10, 1999, at 1:27:01
In reply to Nardil and MAOI dosages, posted by Mark on December 9, 1999, at 17:54:58
> Can Nardil, or any other MAOI, be taken all at once (entire daily dosage at once). Why is it necessary to split up the dose? Do MAOIs have short half-lives like the benzos, or is it due to blood pressure reasons?
The irreversible MAOIs have really short elimination half-lives, but that's not the reason (the half-life of an irreversible MAOI won't affect the % MAO inhibition). Splitting the dose may minimize side effects by spreading them out.
Many doctors will recommend you try to take it all in the morning or early afternoon to avoid insomnia, but my experience has been that it doesn't make a difference what time of day you take them (with the exception of Parnate, which is kind of stimulating) - the insomnia happens regardless!
Posted by Mark on December 10, 1999, at 2:03:46
In reply to Re: Nardil and MAOI dosages, posted by Elizabeth on December 10, 1999, at 1:27:01
Maybe I phrased my question wrong? Is it harmful or less beneficial to take the entire daily dose at once? Also, how long after taking Nardil will my SP begin to improve? I have heard that Parnate works a lot faster, but do the MAOIs in general kick in quickly?
Posted by Elizabeth on December 10, 1999, at 8:46:48
In reply to Re: Nardil and MAOI dosages, posted by Mark on December 10, 1999, at 2:03:46
> Maybe I phrased my question wrong? Is it harmful or less beneficial to take the entire daily dose at once?
You might get more side effects that way. Unless you're getting pretty dangerous side effects (e.g. severe orthostatic hypotension), this probably won't be a big deal.
> Also, how long after taking Nardil will my SP begin to improve?
It varies - give it at least a month.
> I have heard that Parnate works a lot faster, but do the MAOIs in general kick in quickly?
They can, but they won't for everybody.
This is the end of the thread.
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