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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 3 of 3. This is the beginning of the thread.
Posted by Mary on October 10, 1999, at 16:43:52
looking for information in lithium+promethazine toxic interaction resulting on permanent dystonia and severe CNS memory deficit/temporal lobe syndrome.
Posted by saint james on October 10, 1999, at 21:18:31
In reply to drug interaction, posted by Mary on October 10, 1999, at 16:43:52
> looking for information in lithium+promethazine toxic interaction resulting on permanent dystonia and severe CNS memory deficit/temporal lobe syndrome.
James here....
A quick look at the net did not turn up conter indications of this combo. But Bob;s tips site does mention Li in combo with 5ht agents can cause seritonin syndrome go to: http://www.dr-bob.org/tips/split/Serotonin-syndrome-and-neu.html
Out on the web to see what Promethazine is: better know as Phenergan, an Antihistamine, of the phenothiazine-type used as an Antiemetic.
Phenothiazines are anti-psychotics, so they probebly effect 5ht. Also it is interesting that
Phenergan potentates opioids, opioids are assoc with Serotonin-syndrome (when another serotonin meds is taken in combo)From: http://www.rxmed.com/monographs/old/phener2.html
"Promethazine is a phenothiazine derivative. Although the likelihood of those side effects associated with antipsychotic phenothiazines occurring with promethazine seem to be minimal, the possibility exists, especially at higher doses or with prolonged administration."
So it is possible that this is Serotonin-syndrome, NMS, or tardive dyskinesia. Please don't go running to the Doc to blame him/her for causing this. These conditions are uncommon, and some seem more sensitive than others. Also we don't really know all the how's and why's and how much issues. I am also way out of my area of knowlage as I have not taken Li or anti-psychotics b4.
It is more important to make sure this person is seeing a doc who has treated these conditions b4.
Is this person receiving any treatment for this new condition ?james
Posted by Elizabeth on October 12, 1999, at 2:11:16
In reply to Re: drug interaction, posted by saint james on October 10, 1999, at 21:18:31
Mixing neuroleptics and lithium may increase the risk of neurotoxicity (including extrapyramidal symptoms), yup. Promethazine isn't a real neuroleptic, though - it has little effect on dopamine receptors, and as such rarely causes movement disorders (and isn't a very good antipsychotic).
So I guess the answer would be, "maybe, but it seems like a stretch."
This is the end of the thread.
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