![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 741 to 765 of 8406. Go back in thread:
Posted by Ippopo on October 10, 2002, at 9:02:18
In reply to Re: Forest » Mr.Scott, posted by maririp on October 10, 2002, at 7:31:03
Cheers!
Posted by shakingoscar on October 10, 2002, at 9:18:35
In reply to Lexapro and Celexa relative side-effects » pharmrep, posted by dr. dave on October 10, 2002, at 8:10:49
Hi Dr Dave,
I would just like to say one thing.I find I sleep fine on lexapro, and can take it before bedtime and still sleep well.
With citalopram, I could never take it in the evening because I find it far more stimulating than lexapro.
In fact, I am hoping I can stop taking trazodone which I have always needed with SSRIs because I find them so stimulating (except Paxil/seroxat)
Cheers
Posted by mills on October 10, 2002, at 9:21:16
In reply to Anxiety, depression, indecision, posted by Micki on October 9, 2002, at 21:13:21
My depression is related to long term compulsive introspection, worry, self-consciousness, labored thinking, second-guessing, etc., etc., that I have labored under for 25 years, and I can't stop on my own; I haven't been on Lexapro long enough to know how it will work, but Paxil (another SSRI) saved my life, although it had unacceptable side effects; it did help with my OCD and chronic worry
> I am just switching to Lexapro after taking Pamelor for 12 years. I have been on and off antidepressants since I was a teenager. I have always had a difficult time making decisions, and am currently in a state of extreme stress and anxiety over a situation in my love life--choosing which of two people to get involvoed with. I think about it constantly, think I've made a decision, then change my mind the next hour or day. I went to a new psychiatrist who felt this is a form of OCD (although I do not have symptoms such as washing my hands repeatedly).
>
> I lowered the Pamelor, went off it for a few days, took 5 mg Lexapro (mornings) for 3 days and now have taken 10 mg Lexapro for 3 days. I thought I felt better yesterday, today I am extremely stressed out and depressed again. The psychiatrist said the drug should help with the depression in about a 3 or 4 weeks, but that it takes 8 to 12 weeks for it to really affect the obsessive thinking. Anyone have any feedback on how accurate this is? Also, after reading Alan's post about AD's vx BZD's for anxiety disorders, I'm wondering how likely the Lexapro is to help with the anxiety, or if I really need a Bzd. Also wondering if anyone has any comments on Lexapro (or another SSRI) and decision making. I have a terrible time making decisions, and then often think I've made the wrong one and torment myself with second-guessing.
Posted by shakingoscar on October 10, 2002, at 9:30:03
In reply to Re: I AM GOING BACK, posted by Ippopo on October 10, 2002, at 8:56:23
Hi lppopo
For me, anxiety produces many physical symptoms which are:
tremors - inside feels like its shaking
sweating excessively
palpitations
back ache!!!
painfully tight chestIf the anxiety is really bad, I get severe headaches, facial flushing, heavier sweating, loss of balance, confusion, dizziness.. you name it!
Different people suffer anxiety in different ways because each individual can respond to the illness differently.
WRT sexual side effects, for the first 18 months of my illness, relationships and intimacy are just out of the question... For me at least, I think, if Im not happy with me, how can I expect anyone else to be? I dont want to "carry baggage" into a relationship.
However, I brought about my illness through excessive street drug use when I was younger which has knocked my brain chemistry off balance.
Therefore, it is reasonable to think that I should get better, but Im still waiting for that day!
Now that the anxeity and depression are reasonably under control - ie I can work and function almost normally, the natural progression of that is the need for a relationship etc... so the sexual s/e become an issue then ofcourse...
I have always had a really high sex drive and feel like a neutuered (sp?) cat on these pills.
The main mental thought process that causes me problems but I have overcome it with CBD therapy is the thought of imminent disaster when Im in a panic-stricken state (I have suffered with panic attacks too, but not since Ive been on SSRIs).
It is helpful to learn how to cope with the feelings of impending doom, and the pills help with this, but CBT is far more powerful in dealing with actual thought processes. For me, unfortunately, my anxiety is not just based on bad thoughts, but also on chemical imbalance, as already mentioned above, so for many people, therapy + pills are the best solution.
Good luck and be patient and try to think to the future (which is easier said than done ofcourse)
Posted by mills on October 10, 2002, at 9:35:51
In reply to Re: I AM GOING BACK, posted by shakingoscar on October 10, 2002, at 2:38:44
I wholeheartedly agree with oscar on this one; it took me a full 6 weeks plus on Paxil to get any relief from ocd/anxiety/depression, and then I had to work for that much more to regulate the dosage, but once I got it, I found relief and was able to be happy for the first time in a long long time; these medications take patience, at least Paxil does, so hang in there
> Hi lppopo
>
> Im sorry you are suffering too... I am feeling better today, but as Ive been up and down for the last couple of weeks, I dont have any answers for you.
>
> My situation is different. My supid doctor over-prescribed my dose and STARTED me on 30mg which I took for 4 weeks and became really ill because of.
>
> 8 days ago I lowered my dose to 15mg in light of the information I received here. I am still up and down but I think maybe the general direction is improvement...
>
> The only advice I can offer you, from having tried all of the SSRIs, is that patience usually pays dividends, so give it a good shot.
>
> When I first became ill (really severe anxiety) it took me 3 months to settle down on Paxil!!! But the wait was definitely worth it in the end.
>
> Stick with it.
>
> Good luck
Posted by Abacus on October 10, 2002, at 9:47:21
In reply to Re: lexapro and blood pressure » pharmrep, posted by ANXIETY ANN on October 9, 2002, at 21:56:49
I too feel like a zombie during the day. Please let us know how taking it at night works. Thanks.
Posted by dr dave on October 10, 2002, at 12:06:48
In reply to Lexapro news » dr. dave, posted by Anyuser on October 10, 2002, at 8:41:01
It sounds like good news. I don't have comparative data to hand to know whether this
represents a significant improvement over other antidepressants though.As to whether it's good science, that's the $64,000 dollar question, and we have no way of knowing without seeing the details of the actual study. If the study is flawed, the information may be worthless. If it's a sound study, then it's potentially very useful.
What we've got is a marketing claim which may or may not be true. We need to see the details before we can accept it. That's only common sense, in my view.
> From docguide.com:
>
> "Escitalopram 10 to 20 mg/day for treatment of moderately to severely depressed subjects showed ongoing and increasing efficacy throughout a 12-month, open-label study conducted at 97 sites.
>
> "The study's findings were reported at the 15th Congress of the European College of Neuropsychopharmacology (ECNP).
>
> "'The remission rate among the subjects continuing in the open-label study reached 86 percent by week 52,' said lead investigator Alan Wade, MBChB, director at the CPS Clinical Research Centre, in Glasgow, United Kingdom. 'This long-term, primary care-based data begins to fill out the picture of escitalopram as a drug that raises the bar of expectations for effective and tolerable treatment of this group of patients.'"
>
> This study was funded by Lundbeck.
>
> Do you think this is news? Good science?
>
> I wish we could see the data re clinical experience, but it is not reported.
Posted by dr dave on October 10, 2002, at 12:20:11
In reply to Re: Lexapro and Celexa relative side-effects » dr. dave, posted by johnj on October 10, 2002, at 8:59:25
This is the combined data for everyone on any dose of either drug. The average doses were equivalent, in that the average dose of Celexa was about twice that of Lexapro. It is Lundbeck's view, not only mine, that these doses were equivalent. The data show that whether you take s-citalopram alone (eg Lexapro 10mg) or in combination with an equal amount of r-citalopram (eg Celexa 20mg), there is no difference in the side-effects you are likely to experience. So as far as side-effects go, there is no justification for preferring Lexapro over Celexa.
I don't hate Celexa at all. I prescribe it all the time, and started at least one person on it today, because it is an effective antidepressant which I think is remarkably well-tolerated. If I had to take any antidepressant, I think I would take Celexa. What I dislike is what I see as unjustified claims which mislead desparate people. I can see no pharmacological reason why Lexapro should work any differently from Celexa, and I'm not convinved by the results of clinical trials. I think this is reasonable given the long history of new drugs being promoted as new and different and experience showing the advantages have been wildly overstated.
I don't think Lexapro can be any worse than Celexa - it therefore must be an effective and well-tolerated drug, and so I would probably choose it over Paxil, Zoloft etc. However I suspect it's very existence has more to do with extending patent protection than it being any different to Celexa. Here in Europe Celexa has come off-patent and is available at about 50% of the price of the patented version. I'm not going to prescribe a drug that's twice the price of something I already use if it doesn't seem to offer any advantages.
> Were these numbers based on equivalent doses? For example, if you need less lexapro than celexa maybe the side effects are less. Isn't this true for most AD's? The higher I go on pamelor the WORSE the s/e. So, is this a fair comparison because I don't know??? If the %'s that you stated were for 20 mg of lexa and 20 of celexa how fair a comparison is this? Am I missing something Dr. Dave? Sometimes I really get the feeling you hate celexa and lexapro.
> johnj
>
Posted by dr dave on October 10, 2002, at 12:28:02
In reply to Re: Lexapro and Celexa relative side-eff- SLEEP, posted by shakingoscar on October 10, 2002, at 9:18:35
Hi shakingoscar,
I'm glad you're feeling better on the Lexapro. It's difficult to know why you are sleeping better on it than on celexa, but the important thing is that you are, so who cares? If it works, let's not worry too much about it.
People react very individually to antidepressants and there are a whole load of other things going on in most people's lives that will affect that response at any given time. My concern is whether IN GENERAL I can expect people to sleep better on Lexapro than Celexa. The research so far shows that I can't.
It's an important point though to remember that what has been shown to work for a particular patient is more important than what the general research shows.
> Hi Dr Dave,
> I would just like to say one thing.
>
> I find I sleep fine on lexapro, and can take it before bedtime and still sleep well.
>
> With citalopram, I could never take it in the evening because I find it far more stimulating than lexapro.
>
> In fact, I am hoping I can stop taking trazodone which I have always needed with SSRIs because I find them so stimulating (except Paxil/seroxat)
>
> Cheers
>
>
Posted by johnj on October 10, 2002, at 13:22:02
In reply to Re: Lexapro and Celexa relative side-effects » johnj, posted by dr dave on October 10, 2002, at 12:20:11
Thanks Dr. Dave, I appreciate your time and opinion. I do have a few questions in general about AD's. When a person is switching how does one go about doing this? Is there a chart some where that describes how to switch from one class to the another. For ex, I take pamelor and for various reasons need a change. It has not been confirmed and frankly I don't know how it could be, but I have serious s/e after excercise on the TCA.
I have been given some lexapro samples and will not start for another few weeks due to an exam. Is is generally accepted to take the new AD and see if the reaction/remission occurs before reducing the current AD? Or do you titrate down while you titrate up on the new? Lastly, does it matter if one starts at 2.5 mgs, 5 mg or 10 mgs of lexapro, or any other AD for that matter? Could there be higher/harsher s/e at a lower dose?(kind of like you get with remeron). Thanks for any input. I will see my doc again before starting, but I wanted to get another opinion from someone in the field that has seen and has directly worked with such examples. Thank you
johnj
Posted by dr dave on October 10, 2002, at 14:43:23
In reply to Re: Lexapro and Celexa relative side-effects » dr dave, posted by johnj on October 10, 2002, at 13:22:02
There are some guidelines at
http://www.nhslothian.scot.nhs.uk/lothianformulary/appendices/append5.htm#
They are adapted from the Maudsley Prescribing Guidelines, which are my favourite reference. The advice here is, if swapping from tricyclic to citalopram, to halve the dose of tricyclic and introduce citalopram, before gradually withdrawing the tricyclic. This seems sensible to me, but ASK YOUR DOCTOR FIRST! I would continue with this process even if you feel rough and get side-effects, because in a few weeks the side-effects may go and the antidepressant effect kick in.
The higher dose you start on the greater risk of side-effects but the greater probability of an effect. The usual starting dose of Lexapro is 10mg, so I would start on that unless you have a history of being particlarly susceptible to side-effects. Then you could start on five for a week or two and go up to ten.
Best of luck.
> Thanks Dr. Dave, I appreciate your time and opinion. I do have a few questions in general about AD's. When a person is switching how does one go about doing this? Is there a chart some where that describes how to switch from one class to the another. For ex, I take pamelor and for various reasons need a change. It has not been confirmed and frankly I don't know how it could be, but I have serious s/e after excercise on the TCA.
> I have been given some lexapro samples and will not start for another few weeks due to an exam. Is is generally accepted to take the new AD and see if the reaction/remission occurs before reducing the current AD? Or do you titrate down while you titrate up on the new? Lastly, does it matter if one starts at 2.5 mgs, 5 mg or 10 mgs of lexapro, or any other AD for that matter? Could there be higher/harsher s/e at a lower dose?(kind of like you get with remeron). Thanks for any input. I will see my doc again before starting, but I wanted to get another opinion from someone in the field that has seen and has directly worked with such examples. Thank you
> johnj
Posted by dr dave on October 10, 2002, at 15:02:35
In reply to Re: New data » dr. dave, posted by pharmrep on October 9, 2002, at 16:21:04
According to the Lundbeck website, Wyeth are accusing them of cheating in the head-to-head-trial with venlafaxine. I suppose they would, wouldn't they? Allegedly Lexapro was compared to a non-equivalent dose of Effexor. It does mean we ought to reserve judgement until we see the actual data and find out what Wyeth's objections are.
> > A new study has been reported which allegedly shows Lexapro to be more effective than Effexor. This is pretty serious stuff if it is true. There's a link to a story about it in a posting by Anyuser further down the board. If anyone manages to find the study itself I would be very grateful if they could direct me to it.
>
> **** i know the study exists...whether it is done yet or what the results are if done...i dont know, but will see when results are expected
>
Posted by Anyuser on October 10, 2002, at 16:21:49
In reply to Lundbeck accused of cheating in Effexor trial » pharmrep, posted by dr dave on October 10, 2002, at 15:02:35
Do you have access to the following study in full?
European Neuropsychopharmacology
Volume 12, Issue 5, pp. 433-444, October, 2002
Enantiomers' potential in psychopharmacology-a critical analysis with special emphasis on the antidepressant escitalopram
Authors
P. Baumann, D.F. Zullino, C.B. EapAbstract
Stereochemistry is now influencing most areas of pharmacotherapy, with a growing awareness in the field of psychiatry and, more specifically, depression. This is due to the fact that the enantiomers of many chiral drugs may have distinct pharmacological, pharmacokinetic and/or pharmacogenetic profiles. Consequently, in some instances there may be an advantage in using a single enantiomer over the racemic form-thus providing a basis for the development of new therapeutic agents, as well as the potential to improve current treatments. This review highlights some of the potential advantages and disadvantages that using single enantiomers might offer. The principles are exemplified through reference to the stereoselective properties of several established chiral psychotropic drugs, including thioridazine, methadone, trimipramine, mianserin, mirtazapine, fluoxetine and citalopram. Emphasis is given to the treatment of depression and how the potential of one pure enantiomer-escitalopram, the S-enantiomer of the selective serotonin reuptake inhibitor citalopram-appears to be fulfilling its preclinical promise in the clinic.
Keywords: Enantiomer, Depression, Antidepressant, SSRI, Citalopram, EscitalopramPII: s0924977x02000512
© Copyright 1999-2002, Elsevier Science, All rights reserved.
Posted by ZeeZee on October 10, 2002, at 16:33:42
In reply to Re: lexapro and blood pressure » pharmrep, posted by ANXIETY ANN on October 9, 2002, at 21:56:49
Norvasc can cause anxiety and insomnia - I had to stop it for that reason. This may not be the best drug for you if you suffer from anxiety.
Posted by Alan on October 10, 2002, at 18:32:22
In reply to Re: AD's vs. Bzds for Anxiety disorders » Alan, posted by pharmrep on October 9, 2002, at 22:22:18
> ************** what i say is not "company" oriented...just from me. I give a "source" to lend credibility...so as not to be just my opinion. (after all, i did openly identify myself as pharmrep)
> > ============================================
> >
> > I guess that pharmrep is choosing not to answer some very important questions about AD's vis-a-vis their use in treatment of symptoms for anxiety disorders.
> >
> > One would think that a pharmecutical representative would be more than willing to answer these fundamental questions for a very large population of us anxiety sufferers that tried ssri's for many years only to end up on the basic anxiolytic anyway - the lowly benzodiazapine. Or had to augment an ssri with a bzd in the end ....
> >
> > Is that because there are really no legitimate medical answers as to why AD's are presently being promoted as the first line of treatment for the disorder - and not on equal footing with the Benzodiazapines???
> >
> > Why is all of the evidence that the most effective and safe anxiolytic known to medicine - the bzd - brushed aside by the promoting of new AD's in their place rather than along side with the benzodiazapine to give the doctor and patient alike the freedom to choose? Otherwise, isn't freedom being taken away?
> >
> > Would it have anything to do with putting profit before medicine to regain R & D and marketshare?
> >
> > Not meant as just rhetorical questions. Sincerely and honestly wondering...
> >
> > Alan
> >
>
> *** come on alan..if the pharm industry wanted to make money in bzds vs ad's it probably could...it just chooses to focus on ad's because there is more to work with, and more people to aim for...and i believe a proven track record for effectiveness...and why are you attacking me about it? I am here to help not hurt..so be civil=================================================
I'm not attacking you. I'm asking legitimate questions from a pharmecutical authority about specifically why AD's are being pushed in place of BZD's in the treatment of anxiety disorders, that's all.I don't believe the anwers that you are providing are as clearly spelled out for us in the same way that you spell out specifics regarding the single merits of AD's - specifically Lexapro. Certainly the efficacy rates, if they are to be taken at face value, aren't even close to the rates of BZD's.
It's a legitimate question that is important to be addressed for all of us...and I believe that I've asked civily and sincerely several times now.
If you're not sure, an "I'm not sure" will do.
Alan
Posted by Micki on October 10, 2002, at 20:09:47
In reply to Re: Anxiety, depression, indecision » Micki, posted by johnj on October 9, 2002, at 22:24:26
> Hi Micki
> I am also on pamelor(nortryptline) and my pdoc has given me lexapro and told me to take it and get stable on it before lowering my dose of pamelor. I have been on it for 10 years and the s/e are terrible, dry mouth, constipation, urinary retention, etc. What dose of pamelor are you on? Talk to your doc about how to switch the dose since 12 years is a long time! I also take a benzo, and have thought about monotherapy too. It is a tough decision and my pdoc says no. My pdoc didn't want me to lower the pamelor before the lexapro was working AND if it proves to be right for me. If it is not for me I would not have any AD in my system. You could be having some withdrawl symptoms from your lowrering of pamelor. I believe the dose should be lowered over a 2 to 4 week period. Please check all this out. Also, maybe the lack of decision making is just that....maybe you are not sure and that would definately give me some anxiety, which would be normal. take care
> johnjI was taking 50 mg pamelor. My prescription was actually for 75 mg, which probably worked better, but I lowered the dose on my own years ago while I was feeling stable because of the severe dry mouth and constipation. I went down to 25 mg for 5 days, then off for 4 days before starting the Lexapro. The indecision is nothing new, however. As I child I would go to the library and leave with no books, because I couldn't decide which books to take out. Just talked to my psychiatrist who is prescribing a second drug to try to help with the anxiety and what she calls ruminating. Unfortunately, I did not write down the name of it. I won't pick it up till Saturday, will post again when I get it. She says it's not addicting, unlike Xanax, which I took for a while many years ago during a crisis.
Posted by Dr. Bob on October 10, 2002, at 20:31:58
In reply to Re: AD's vs. Bzds for Anxiety disorders » pharmrep, posted by Alan on October 10, 2002, at 18:32:22
> > why are you attacking me about it?
> >
> > pharmrepPlease remember not to post anything that could lead others to feel accused or put down...
> I'm not attacking you. I'm asking legitimate questions from a pharmecutical authority about specifically why AD's are being pushed in place of BZD's in the treatment of anxiety disorders, that's all.
>
> AlanAnd also not to pressure others. (BTW, I don't think he's claimed to be any sort of "authority"...) Thanks,
Bob
PS: Follow-ups regarding posting policies, and complaints about posts, should be redirected to Psycho-Babble Administration; otherwise, they may be deleted.
Posted by ANXIETY ANN on October 10, 2002, at 21:08:47
In reply to Lexapro and Celexa relative side-effects » pharmrep, posted by dr. dave on October 10, 2002, at 8:10:49
does anyone experience intense hot flushing with Lexapro? 4 days on Lexapro and sometimes i get this intense hot feeling throughout my whole body. I don't turn red or anything, but it is very uncomfortable, especially when it wakes you up at night. These flushes last about 20-30 minutes and slowly dissapate. thanks for any help
Posted by Ippopo on October 10, 2002, at 22:12:43
In reply to Re: Anxiety, depression, indecision, posted by Micki on October 10, 2002, at 20:09:47
I thought it was just me but I didn't realize indecission was anything other than just being fussy. As a child my sister and I were given x amount of $ to buy a toy every Friday after Dad came home from work. My sister had no problems finding something. On the other hand my parents and I walked up and down the aisles fo what would seem like an hour til they decided for me. This is been life in not all but many ways.
Could you explain how meds have helped you with this?
Thank you
Posted by Alan on October 10, 2002, at 22:31:14
In reply to Re: AD's vs. Bzds for Anxiety disorders » Alan, posted by pharmrep on October 9, 2002, at 22:22:18
> *** come on alan..if the pharm industry wanted to make money in bzds vs ad's it probably could...it just chooses to focus on ad's because there is more to work with, and more people to aim for...and i believe a proven track record for effectiveness...
===============================================Would you please elaborate further about the need to focus on AD's at the expense of Bzd's in the treatment of anxiety disorders....causing doctors to mistakenly offer only AD monotherapy instead of both BZD monotherapy AND AD monotherapy on equal footing for their patients' clinical trials?
Posted by jane d on October 10, 2002, at 23:28:50
In reply to Re: AD's vs. Bzds for Anxiety disorders » pharmrep, posted by Alan on October 10, 2002, at 22:31:14
> Would you please elaborate further about the need to focus on AD's at the expense of Bzd's in the treatment of anxiety disorders....causing doctors to mistakenly offer only AD monotherapy instead of both BZD monotherapy AND AD monotherapy on equal footing for their patients' clinical trials?
>Alan,
Pharmrep has said he is a sales representative for a company, not a representative of the industry as a whole. It's not reasonable to expect him to be able to answer questions about overall drug development or marketing policies. Probably you and the other posters on this board that have a personal interest in bzds know as much as anybody else.
Jane
Posted by Alan on October 11, 2002, at 0:57:04
In reply to Re: AD's vs. Bzds for Anxiety disorders, posted by jane d on October 10, 2002, at 23:28:50
> > Would you please elaborate further about the need to focus on AD's at the expense of Bzd's in the treatment of anxiety disorders....causing doctors to mistakenly offer only AD monotherapy instead of both BZD monotherapy AND AD monotherapy on equal footing for their patients' clinical trials?
> >
>
> Alan,
>
> Pharmrep has said he is a sales representative for a company, not a representative of the industry as a whole. It's not reasonable to expect him to be able to answer questions about overall drug development or marketing policies. Probably you and the other posters on this board that have a personal interest in bzds know as much as anybody else.
>
> Jane
============================================Why don't we let the parmecutical representative speak for themselves? They are well armed to field any questions about their new medications in relation to others - that's what salesman do.
Someone as well versed in psychotropics and their chemistry in the treatment of anxiety disorders - as I see technical information, statistics, etc cited about how effective Lexapro is - in medical parlance that would make the average consumer's head spin, why would it be unreasonable to ask why they think this medication is more effective for treating anxiety disorders than the well established bzds?
I'm sure that such sophisticated knowledge of the disorder, symptomology, and side effects during treatment would qualify them (if some think only marginally) to comment on why they think their product is more effective in the treatment of anxiety disorders than bzds.
After all, as they have shown, it is their specific area of expertise. No one is asking for a commentary or analysis of the pharm industry in general here as I understand it...
Alan
Posted by shakingoscar on October 11, 2002, at 1:06:19
In reply to Re: Lexapro and Celexa relative side-effects » dr dave, posted by johnj on October 10, 2002, at 13:22:02
Hi Johnj,
PLEASE TAKE MY ADVICE ON THIS POINT.Switching from 60mg citalopram to 30mg lexapro has caused me a month of agony.
Whatever you do, start low on lexapro and work up until you find the right dose.
DO NOT ASSUME THAT YOU TAKE HALF OF YOU CITALOPRAM DOSE.
My doctor has done this and its caused me to be really ill the last few weeks. I am in the process still of adjusting to 15mg lexapro (still not sure if its the right dose), and I changed dose 9 days ago and Im still getting "electric shocks" in the brain as I get used to the new dose.
BE CAREFUL!!!!!!!!!!!!!!!!!!!!!!!!!!
Good luck
Posted by Ippopo on October 11, 2002, at 1:30:29
In reply to Re: Lexapro and Celexa relative side-effects, posted by shakingoscar on October 11, 2002, at 1:06:19
Hi ShakingOscar,
Well this is 30hrs into the dossage of 20mgs of lezapro. I've felt electric shocks to the brain but it may have been with EffexorXR. Since the change of meds started 07/29/02, I don't remember too much. BummerHank, electric shocks to the brain are not very nice.
Anyway, as the 31st hr approaches I want to keep talking but the rest of me wants to sleep. (Late night Pierogis may be the culprit)
It's nice to want to do constructive things again.
I hope this isn't just a here today gone tomorrow s/e. I do have a friend who switched from celexa to lexapro. He spoke of a resurgence of energy. Have you experienced anything like this?
Ippopo
Posted by pharmrep on October 11, 2002, at 1:30:51
In reply to Lundbeck accused of cheating in Effexor trial » pharmrep, posted by dr dave on October 10, 2002, at 15:02:35
** I dont know about lundbeck...just forest studies here in the US...most studies that we use in the US are done here...I dont know why, but thats the case (probably an FDA thing)...Lundbeck and European studies are not always used...maybe due to different methods and variables.
> According to the Lundbeck website, Wyeth are accusing them of cheating in the head-to-head-trial with venlafaxine. I suppose they would, wouldn't they? Allegedly Lexapro was compared to a non-equivalent dose of Effexor. It does mean we ought to reserve judgement until we see the actual data and find out what Wyeth's objections are.
>
> > > A new study has been reported which allegedly shows Lexapro to be more effective than Effexor. This is pretty serious stuff if it is true. There's a link to a story about it in a posting by Anyuser further down the board. If anyone manages to find the study itself I would be very grateful if they could direct me to it.
> >
> > **** i know the study exists...whether it is done yet or what the results are if done...i dont know, but will see when results are expected
> >
>
>
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